To provide a pharmaceutical preparation containing an isoquinoline-6-amino derivative being stable even at high temperature.SOLUTION: A pharmaceutical preparation has an aqueous composition stored in a transparent container, the aqueous composition containing (A) a compound of the following formula (including a tautomer) or a salt thereof or their solvates and (B) a prostaglandin (Rand Rindependently represent H or a C-Calkyl group; Ris H or OH; A is -CH(R)- or -CH-CH(R)-; Ris an optionally substituted C-Caryl group, or an optionally substituted 5-10 membered heteroaryl group).SELECTED DRAWING: None【課題】高温でも安定なイソキノリン-6-アミノ誘導体を含有する医薬製剤の提供。【解決手段】(A)下式の化合物(互変異性体も含む)若しくはその塩又はそれらの溶媒和物及び(B)プロスタグランジン類を含有する水性組成物が、透明容器に収容されてなる、医薬製剤。(R1とR2はそれぞれ独立してH又はC1~C4アルキル基;R3はH又はOH;Aは-CH(R4)-又は-CH2-CH(R4)-;R4は置換基を有してもよいC6~C10アリール基、又は置換基を有してもよい5~10員のヘテロアリール基)【選択図】なし