HINNER, MARLON,ROTHE, CHRISTINE,OLWILL, SHANE,BEL AIBA, RACHIDA SIHAM,MOEBIUS, ULRICH,SCHLOSSER, CORINNA,JAQUIN, THOMAS JEAN
申请号：
CA2980840
公开号：
CA2980840A1
申请日:
2016.05.04
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The disclosure provides a fusion polypeptide specific for both CD137 and HER2/neu, which fusion polypeptide can be useful for directing CD137 clustering and activation to HER2/neu- positive tumor cells. Such fusion polypeptide can be used in many pharmaceutical applications, for example, as anti-cancer agents and/or immune modulators for the treatment or prevention of human diseases such as a variety of tumors. The present disclosure also concerns methods of making the fusion polypeptide described herein as well as compositions comprising such fusion polypeptide. The present disclosure further relates to nucleic acid molecules encoding such fusion polypeptide and to methods for generation of such fusion polypeptide and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of such fusion polypeptide as well as compositions comprising one or more of such fusion polypeptides.
