The present invention relates to antimicrobial peptoids with improved selectivity to bacteria and a use thereof. Specifically, the present invention relates to antimicrobial peptoids having high antimicrobial activity and greatly decreased toxicity to animal cells. The antimicrobial peptoids of the present invention show excellent antimicrobial activity against bacteria and exhibit low cytotoxicity to animal cells due to altered degree of folding in helical structure or altered charge characteristics. Therefore, the antimicrobial peptoids of the present invention have improved selectivity to bacteria, and thus can be usefully used as antimicrobial compositions.
