The invention belongs to the medicine field, and relates to the medical application of arctigenin, and in particular relates to application of the arctigenin in preparation of drugs for treatment of digestive tract ulcerative diseases, and the drugs are preferably injection preparations. The research proves that: the arctigenin has inhibitory effects on rat water immersion stress gastric ulcer, pyloric ligation gastric ulcer, mice gastric ulcer induced by absolute ethanol, rat experimental duodenal ulcer and the like, can reduce the ulcer index, and has significant inhibitory effects on rat ulcerative colitis induced by acetic acid. The arctigenin used in treatment of the digestive tract ulcerative diseases has the advantages of definite curative effect and low toxic and side effects, so that the arctigenin has a wide application prospect.
