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New derivatives of 6,11-dihydro-5H-benzo [d] imidazo [1,2-a] acepins used as histamine H4 receptor ligands
专利权人:
BIOPROJET
发明人:
BERREBI BERTRAND, ISABELLE,BILLOT, XAVIER,CALMELS, THIERRY,CAPET, MARC,KRIEF, STÉPHANE,LABEEUW, OLIVIER,LECOMTE, JEANNE-MARIE,LEVOIN, NICOLAS,LIGNEAU, XAVIER,ROBERT, PHILIPPE,SCHWARTZ, JEAN-CHARLES
申请号:
ES13170666
公开号:
ES2540976T3
申请日:
2013.06.05
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
A compound of formula (I): ** Formula ** in which * R1 is selected from: - an alkyl optionally substituted by an amino, alkylamino, dialkylamino group or a monocyclic or bicyclic heterocycle having a nitrogen atom; and - a monocyclic or bicyclic heterocycle having a nitrogen atom, said heterocycle being optionally substituted by an alkyl group; * R2, R3, R4 and R5 identical or different are independently selected from: - hydrogen-; - halogen-; - alkyl-; - alkenyl-; - aryl- optionally substituted; - aralkyl-; - alkylamino-; - dialkylamino-; - alkoxy; - aralkoxy; - alkylsulfanyl-; * R6, R7, R8 and R9 identical or different are independently selected from: - hydrogen-; - alkyl-; * R10 and R11 identical or different are chosen independently from the following list L1: - hydrogen-; - halogen-; - alkyl-; - cycloalkyl-; - cycloalkylalkyl-; - cycloalkylalkenyl; - alkenyl-; - cycloalkenyl-; - alkynyl. - aril-; - aralkyl-; - aralkenyl; - aralquinyl-; - aralkoxyalkyl-; - aryloxyalkyl-; - aralkoxyalkenyl-; - aryloxyalkenyl-; - arylcarbonyl-; - arylsulfanyl-; - aralkylsulfanyl-; - heteroaryl-; - heteroarylalkyl-; - heteroarylalkenyl-; - heteroarylalkyl-; - heteroarylsulfanyl-; - heteroaralkylsulfanyl-; - heterocycle-; - heterocyclosulfanyl-; - alkoxy; - alkylsulfanyl-; - cycloalkylsulfanyl-; - cyano-; - alkylcarbonyl-; - aminocarbonyl-; - alkylaminocarbonyl-; - dialkylaminocarbonyl-; - arylaminocarbonyl-; - aralkylaminocarbonyl-; - N-alkyl-arylaminocarbonyl-; -N-alkyl-aralkylaminocarbonyl-; - alkoxycarbonyl-; - alkoxycarbonylalkyl-; - alkoxycarbonylalkenyl-; - alkoxycarbonylalkyl-; - alkoxycarbonylheterocycle-; - alkoxycarbonylheterocyclosulfanyl-;Un compuesto de fórmula (I):**Fórmula** en la que * R1 se elige entre: - un alquilo sustituido opcionalmente por un grupo amino, alquilamino, dialquilamino o un heterociclo monocíclico o bicíclico que posee un átomo de nitrógeno; y - un heterociclo monocíclico o bicíclico que posee un átomo de nitrógeno, estando dicho heterociclo opcio
来源网站:
中国工程科技知识中心
来源网址:
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