SHIN, Youngsook;CUSHING, Timothy D.;AMGEN INC.;LOHMAN, Julia Winslow
发明人:
CUSHING, Timothy D.,LOHMAN, Julia Winslow,SHIN, Youngsook
申请号：
USUS2011/061141
公开号：
WO2012/068343A1
申请日:
2011.11.17
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Substituted bicyclic heteroaryls having the general formula (I) and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p1 108 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML), Myelodysplastic syndrome (MDS), myeio-proiiferative diseases (MPD), Chronic Myeloid Leukemia (CML), T-cell Acute Lymphoblastic leukaemia (T-ALL), B-cell Acute Lymphoblastic leukaemia (B-ALL), Non Hodgkins Lymphoma (NHL), B-cell lymphoma and solid tumors, such as breast cancer.L'invention concerne des hétéroaryles bicycliques substitués de formule générale (I) et des compositions les renfermant, destinés à traiter l'inflammation générale, l'arthrite, les maladies rhumatismales, l'arthrose, les troubles inflammatoires de l'intestin, les troubles inflammatoires oculaires, les troubles inflammatoires de la vessie ou l'instabilité vésicale, le psoriasis, les affections cutanées à composantes inflammatoires, les états inflammatoires chroniques, comprenant entre autres les maladies auto-immunes telles que le lupus érythémateux disséminé (LED), la myasthénie grave, la polyarthrite rhumatoïde, l'encéphalomyélite aiguë disséminée, le purpura thrombocytopénique idiopathique, la sclérose en plaques, le syndrome de Sjögren et l'anémie hémolytique auto-immun
