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COMPOSES 8-FLUOROPHTALAZIN-1(2H)-ONE COMME INHIBITEURS DE L'ACTIVITE BTK
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CRAWFORD, JAMES JOHN,ORTWINE, DANIEL FRED,WEI, BINQING,YOUNG, WENDY B.
申请号:
CA2853967
公开号:
CA2853967A1
申请日:
2012.11.02
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
8-Fluorophthalazin-1(2h)-one compounds of Formula (II) where one or two of X1, X2, and X3 are N, are provided, including stereoisomers, tautomers, and pharmaceutically acceptable salts thereof, useful for inhibiting Btk kinase, and for treating immune disorders such as inflammation mediated by Btk kinase. Methods of using compounds of Formula (II) for in vitro, in situ, and in vivo diagnosis, and treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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