Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include at least one RNA polynucleotides having an open reading frame encoding at least one varicella zoster virus (VZV) antigen. Methods for preparing and using such vaccines are also described.本發明之態樣係關於核酸疫苗。該等疫苗包括至少一種具有編碼至少一種水痘帶狀疱疹病毒(VZV)抗原之開放閱讀框架之RNA聚核苷酸。亦描述了製備及使用該等疫苗之方法。