The present invention relates to a method for the long term treatment of gastrointestinal disorders in a human subject, which comprises administering an effective amount of a halogenated prostaglandin compound and/or its tautomer to the subject. The method induces substantially no electrolyte shifting during the term of the treatment.The compound used in the present invention can improve quality of life in the human subjects with gastrointestinal disorders, are similarly effective in treating male and female human subjects, and also effective in a human subject aged even 65 years and older.本發明係關於長期治療人類胃腸道疾病患者的方法，包括投予患者有效量的鹵素化前列腺素化合物及/或其互變異構物組成物。治療期間，該方法實質上未產生電解質偏移現象。本發明使用的化合物能改善人類胃腸道疾病患者的生活品質，對治療男性與女性病人有類似效果，甚至對年齡65歲及65歲以上患者亦有療效。
