A sensor fixture is provided for operatively attaching a photoacoustic (PA) sensor to a patient. The sensor fixture includes an acoustic coupling agent that is configured to allow the transmission of both acoustic energy and light therethrough. The sensor fixture includes a bracket configured to be affixed to skin of the patient. The bracket includes a cavity, a patient side, and a sensor side. The acoustic coupling agent is held within the cavity. The patient side includes a patient opening that is configured to expose the acoustic coupling agent along the patient side. The sensor side includes a sensor opening that is configured to expose the acoustic coupling agent along the sensor side. The sensor side includes a sensor cradle that is configured to hold the PA sensor such that the PA sensor is operatively attached to the acoustic coupling agent for receiving an acoustic response from the patient.
