President and Fellows of Harvard College;Dana-Farber Cancer Institute, Inc.
发明人:
Kenneth C. Anderson,James E. Bradner,Edward Franklin Greenberg,Teru Hideshima,Nicholas Paul Kwiatkowski,Ralph Mazitschek,Stuart L. Schreiber,Jared Shaw,Stephen J. Haggarty
申请号：
US14679800
公开号：
US09572854B2
申请日:
2015.04.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative disorders). The invention provides methods and pharmaceutical compositions for treating these diseases using aggresome inhibitors or combinations of aggresome inhibitors and proteasome inhibitors. The invention further relates to methods and pharmaceutical compositions for treating multiple myeloma. New HDAC/TDAC inhibitors and aggresome inhibitors are also provided as well as synthetic methodologies for preparing these compounds.
