The sensor frame that a kind of life sign measurement device comprises sensor fastening device, kept by this sensor fastening device, the light sensing system 104 and the output unit that keep by sensor frame.Sensor fastening device is suitable for placing against experimenters anatomical position, is exactly artery in this anatomical position.The photodetector that light sensing system 104 comprises optical waveguide, the light supply apparatus of luminous energy is provided and is used for detecting the amount of the luminous energy that leaves optical waveguide to optical waveguide.Light sensing system 104 is according to the compression or the crooked sensing arterial pulse of at least a portion of optical waveguide, this compression or the crooked minimizing that causes leaving the light quantity of optical waveguide.Output unit produces the measurement result of vital sign based on the signal that receives from photodetector to small part.