Zhou Han-Jie,Sun Congcong M.,Shenk Kevin D.,Laidig Guy J.
申请号：
SI200632181
公开号：
SI2623113T1
申请日:
2006.11.09
申请国别(地区):
SI
年份:
2017
代理人:
摘要：
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases associated with the proteasome. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. Oral administration of these peptide-based proteasome inhibitors is possible due to their bioavailability profiles.
