ANTIBODY CAPABLE OF BINDING THYMIC STROMAL LYMPHOPOIETIN, NUCLEIC ACID ENCODING SAME, EXPRESSION VECTOR, HOST CELL, HYBRIDOMA, METHOD OF PRODUCING THE ANTIBODY AND USE THEREOF
COMEAU Michael, R.,Комо, Майкл Р.,SMOTHERS James, F.,Смозерс, Джеймс Ф.,YOON Bo-Rin, P.,Юн, Бо-рин П.,MEHLIN Christopher,Мелин, Кристофер
申请号：
EA201000471
公开号：
EA022796B1
申请日:
2008.09.09
申请国别(地区):
EA
年份:
2016
代理人:
摘要：
The present invention relates to an isolated antibody that specifically binds polypeptide of the thymic stromal lymphopoietin (TSLP) and comprises: a) a light chain variable domain comprising: i) a light chain CDR1 sequence comprising amino acid sequence SEQ ID NO: 13 ii) a light chain CDR2 sequence comprising amino acid sequence SEQ ID NO: 60 and iii) a light chain CDR3 sequence comprising amino acid sequence SEQ ID NO: 105 and b) a heavy chain variable domain comprising: i) a heavy chain CDR1 sequence comprising amino acid sequence SEQ ID NO: 145 ii) a heavy chain CDR2 sequence comprising amino acid sequence SEQ ID NO: 173 and iii) a heavy chain CDR3 sequence comprising amino acid sequence SEQ ID NO: 212 or a) a light chain variable domain having a sequence selected from the group consisting of: i) an amino acid sequence that is at least 80% identical to SEQ ID NO: 363 ii) an amino acid sequence encoded by a polynucleotide sequence that is at least 80% identical to SEQ ID NO: 362 and iii) an amino acid sequence encoded by a polynucleotide sequence that hybridizes under moderately stringent conditions to the complement of a polynucleotide consisting of SEQ ID NO: 362 and b) a heavy chain variable domain having a sequence selected from the group consisting of: i) an amino acid sequence that is at least 80% identical to SEQ ID NO: 361 ii) an amino acid sequence encoded by a polynucleotide sequence that is at least 80% identical to SEQ ID NO: 360 and iii) an amino acid sequence encoded by a polynucleotide sequence that hybridizes under moderately stringent conditions to the complement of a polynucleotide consisting of SEQ ID NO: 360 or a light chain variable domain comprising sequence SEQ ID NO: 363, and a heavy chain variable domain comprising sequence SEQ ID NO: 361. The present invention also provides an isolated nucleic acid encoding the antibody, a recombinant expression vector, a host cell comprising such vector, a hybridoma producing the antibody, as well as a
