Zhaoli Zhang,Shidong Liu,Zhonghao Zhuo,Xiaoming Ji
申请号：
US13877427
公开号：
US08927690B2
申请日:
2011.09.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
A process for purifying cyclic lipopeptide compounds or salts thereof comprising the steps of: (1) charging a crude compound of Formula I onto a macroporous adsorption resin (2) washing the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as a washing liquid and (3) eluting the compound of Formula I from the macroporous adsorption resin using water, an organic solvent or a mixed solution of an organic solvent and water as an eluent. The purification method has the advantages of using a small amount of organic solvents, using no silica gel, and causing little damage to the environment the purity of the collected compound of formula I is also improved as compared with the methods previously disclosed.
