HEATHER FINLAY,GEORGE O. TORA,JI JIANG,SOONG KIM,TAMMY C. HOON - WANG,JAMES A. JOHNSON,ZULAN PI,JENNIFER X. QIAO
申请号：
ARP130102436
公开号：
AR092854A1
申请日:
2013.07.08
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
1. Claim 1: a compound characterized by formula (1),Either a stereoisomer, a tautometer, or a salt, which is pharmaceutically acceptable, wherein R1 is a choice independent of halogen, CN, co-r690,-CONH (CH) -R1. Substituted phenyl with 0-3r74919；a. Heteromorphic period of 5 to 6 members, including carbon atom and 1-4 heteromorphic atoms selected from n.758080；a. O and S (o)a. Replacing heterocycle with 0-3 r7491； 1R² is independently selected, in each case, from halogen, OH, C₁₋₄ alkyl,C₁₋₄ alkoxy,C₁₋₄ haloalkyl,hello Coxi C₁₋₄,CN, NH₂,No.8322；NH (alquilo OLD),N (C₁₋₄ alkyl) ₂,CO₂H, CO₂ (alquilo C₁₋₄) y CONH₂；R³ is independently selected from: C₁₋₆ alkyl substituted with 0-2 R⁷,C₂₋₆ alkenyl,C₁₋₆ haloalkyl,C₁₋₆ alkoxy,-(ch832244) - (o) 8345； - (carbocnicro c832318326 replaced by 0-3 r74955)；-(ch832244)； - (o) 8345； - (different periods of 5-6 members, including carbon atoms and 1-4 non normal atoms selected from n.758080)；a. O and S (o)a. The nonorthodox period is replaced by 0-2r749595；R830808 is independent of formula residues (2) and (3)；R⁵ is independently selected from: CO₂ (C₁₋₄ alkyl),NH.8322；NH (alquilo OLD),N (C₁₋₄ alkyl) ₂,Conh83222,CONH (lease c832318324 replaced by 0-1 r75844),CON (C₁₋₄ alkyl) ₂,NHCOR⁸,Nhonh (lessor c8321c83318324),SO₂R⁹,NHSO₂NH₂,1. So83222nhc (rent c8332131)NHSO₂ (C₁₋₄ alkyl),NHSO₂NHCO₂ (C₁₋₄ alkyl),NHSO₂NHRʲ,SO NHSO (haloalquilo C)N (alquilo C) SO NHN (CO -alquilo C) SO (alquilo C)CONH (cicloalquilo C)The remaining formula (4) and the remaining formula (5)；R8310 is independent of a set of formulas (6),1. Phenyl and a 5 to 6-member heteromorphism, including carbon atom and 1-4 heteromorphism atom selected from n.758080；a. O and S (o)a. Phenyl and isopropene were changed to 0-2r75844；R⁷ is independently selected from: OH, halogen, C₁₋₄ alkoxy,C₁₋₄ haloalkyl,hello Coxi C₁₋₄,NH.8322；CO₂H, CO₂ (alquilo C₁₋₄),SO₃H, CONHRᵈ,NHCONHRᵈ,NHCO₂Rᵈ,a residue of formula (7) and 5-6 membered heterocycle comprising carbon atoms and 1-4 heteroatoms select
