DEFECTIVE SINDBIS VIRAL VECTORS

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专利权人:

NEW YORK UNIVERSITY

发明人:

HURTADO, ALICIA,MERUELO, DANIEL

申请号：

CA2602730

公开号：

CA2602730C

申请日:

2006.03.29

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

Disclosed herein are new defective Sindbis viral vectors made from wild typeAr-339 Sindbis virus, with differencesin replicase and envelope proteins between JT vectors and consensus Sindbisvirus sequences, and also between JT and Ar-339vectors. Also disclosed are plasmids used for the production of the vectors,methods for producing the vectors, methods for treatingmammals suffering from tumors and pharmaceutical formulations for use in thetreatment methods.

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