KLAUS DR. WENING,LUTZ DR. BARNSCHEID,SEBASTIAN DR. SCHWIER
申请号：
ARP130101225
公开号：
AR090695A1
申请日:
2013.04.16
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
A pharmaceutical dosage form comprising a tamper resistant pharmacologically Active Ingredient is embedded in a Matrix of prolonged releaseWhich comprises a prolonged Release Matrix material selected from the group consisting of Acrylic Polymers and non-ionic and Waxy materials which provides extended release of pharmacologically Active Ingredient, resistance against solvent extraction Ventes, Ground Resistance and resistance against Immediate Release Dose in aqueous ethanol.Claim 2: pharmaceutical dosage form as described in claim 1, wherein the Matrix material prolonged Release includes a non-ionic Acrylic Polymer which is derived from a monomer mixture comprising a First alkyl acrylate c u2081 u208b (MET) And by Land. A Second alkyl acrylate c u2081 u208b u2084 (MET) which differs from the first alkyl acrylate c u2081 u208b u2084 (MET).Claim 6: pharmaceutical dosage form as described in any of the preceding Claims, wherein the Matrix material prolonged Release includes a Waxy material which is selected from the group consisting of monoglycerides, diglycerides, triglyceride S, Fatty Acid Esters with Fatty alcohols and paraffins.Claim 1: pharmaceutical dosage form as described in claim 10, wherein the Matrix material is a hard prolonged Release additional Fat according to Ph. EUR. Or a Polymer selected from the group consisting of Acrylic Polymer Ionic, polialquilenglicoles, polyalkylene oxides, Cellulose and Cellulose Derivatives.Claim 16: pharmaceutical dosage form as described in any of the preceding Claims, which is Extruded by Fusion.Una forma de dosificación farmacéutica resistente a la adulteración que comprende un ingrediente farmacológicamente activo incrustado en una matriz de liberación prolongada, la cual comprende un material de matriz de liberación prolongada que se selecciona del grupo que consiste de polímeros acrílicos no iónicos y materiales cerosos y la cual proporciona liberación prolongada sobre el ingrediente farmacológicamente activo, resiste
