compound, pharmaceutical composition, pharmaceutical kit for treating a cancer, and methods for treating a disease and / or condition and / or disorder and for synthesizing a compound.
ALAN WISE,MICHAEL KICZUN,PHILLIP COWLEY,SUSAN DAVIS
申请号：
BR112017009134
公开号：
BR112017009134A2
申请日:
2015.11.02
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
A tryptophan-2,3-dioxigenase (tdo) and / or indoleamine-2,3-dioxigenase (acid) inhibitor compound is provided for use in a medicament, the compound of which comprises the following formula: wherein x1 and x2 may be the same or different and each is independently selected from c, n, o； x3, x4, x5 and x6 may be the same or different and each is independently selected from c and n； each bond represented by a dotted line may be present or absent as long as at least one such bond is present； r1, r2, r3, r4, r5 and r6 may be present or absent and may be the same or different, and each is independently selected from h and a substituted or unsubstituted organic group, provided that the number of groups r1, r2, r3, r4, r5 and r6 present is such that the respective valencies of x1, x2, x3, x4, x5 and x6 are retained； and wherein at least one of r5 and r6 comprises a group y, wherein y is a group having a formula selected from the following: wherein 1 may be present or absent, and may be a substituted or unsubstituted organic linking group. substituted； r31 and r32 may be the same or different and are selected from h and a substituted or unsubstituted organic group； each r34 may be the same or different and is selected from h and a substituted or unsubstituted organic group； R35 is selected from a substituted or unsubstituted alcohol group or ether group； each r36 may be the same or different and is selected from h and a substituted or unsubstituted organic group； x7 may be selected from c and n； x8, x9, x10, x11, x12, x13, x14, x15 and x16 can be the same or different and each is independently selected from c, n, o and s； each link represented by a dotted line may be present or absent； and each r313 may be the same or different and is selected from h and a substituted or unsubstituted organic group.é provido um composto inibidor de triptofano-2,3-dioxigenase (tdo) e/ou indoleamina-2,3-dioxigenase (ido) para uso em medicamento, cujo composto compreende a seguinte fórmula: em q
