PROBLEM TO BE SOLVED: To provide a compound which can inhibit the formation of amyloid fibrils, an amyloid fibril formation inhibitor comprising the compound, and a neurodegenerative disease therapeutic or preventive.SOLUTION: An amyloid fibril formation inhibitor comprises a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, or their solvates [R1 and R2 each independently represent H, an alkyl group, a cyano group or the like R3 and R4 independently represent H, an alkyl group or the like R3 and R4 may together form a ring Ar1 and Ar2 independently represent a substituted/unsubstituted aryl group or a substituted/unsubstituted heteroaryl group X and Y independently represent a single bond, -C(=O)- and the like, Z is O or CH2 n is an integer of 1-3].SELECTED DRAWING: NoneCOPYRIGHT: (C)2017,JPO&INPIT【課題】アミロイド線維の形成を抑制することができる化合物、当該化合物を含むアミロイド線維形成抑制剤および神経変性疾患の治療薬または予防薬の提供。【解決手段】式(I)で表される化合物もしくはその薬学的に許容される塩またはそれらの溶媒和物を含んでなる、アミロイド線維形成抑制剤。[R1及びR2は夫々独立にH、アルキル基、シアノ基等;R3及びR4は夫々独立にH、アルキル基等;R3及びR4は、共同して環を形成してもよい;Ar1及びAr2は夫々独立に置換/非置換のアリール基又は置換/非置換のヘテロアリール基;X及びYは夫々独立に単結合、-C(=O)-等、ZはO又はCH2;nは1~3の整数]【選択図】なし
