(57)< Abstract > Requires remedy although inside the vein it prescribes to the patient who we to be suitable, the active ingredient formula (ii): < Conversion 1 > So new production method of the stabilization freeze drying karubapenemu antibiotic formulation which is displayed. This method while approximately maintaining pH in 7.0 - approximately 8.0, approximately mixes unstable one sodium salt karubapenemu with the sodium bicarbonate solution in the temperature range of 0 - approximately 5C, filters the solution which is obtained, bottle stuffing does under sterilization condition, freezes dries and consists of the fact that the formulation is produced.治療を要する患者に静脈内投与するのに適しており、活性成分が式(II):【化1】で表される安定化凍結乾燥カルバペネム系抗生物質製剤の新規製造方法。本方法はpHを約7.0~約8.0に維持しながら約0~約5℃の温度範囲で不安定な一ナトリウム塩カルバペネムを重炭酸ナトリウム溶液と混合し、得られた溶液を濾過し、滅菌条件下で壜詰し、凍結乾燥して製剤を製造することからなる。
