Hack, Michael D,Allison, Brett D,Branstetter, Bryan James,Breitenbucher, James Guy,Hawryluk, Natalie A,Lebsack, Alec D,McClure, Kelly J,Merit, Jeffrey E
申请号：
NO20084411
公开号：
NO341676B1
申请日:
2008.10.21
申请国别(地区):
NO
年份:
2017
代理人:
摘要：
A process for the separation of a highly volatile component from a mixture of substances under the conditions of the short path of - or molecular distillation, in which the substance mixture is heated, the volatile component at least partially vaporizes and then the resulting steam is condensed, and in which the volatile component to be separated in the region of the location of the condensation with a liquid is brought into contact, characterized in that the volatile component to be separated in the region of the location of the condensation with a liquid (washing liquid) is brought into contact, in which they are connected to the effect, that a lowering of the concentration of the readily volatile component to be separated in the region of the location of the condensation is achieved by dilution.Visse tetrahydro-pyrimidoazepinforbindelser er beskrevet, som er anvendelig som TRPV I -modulatorer. Slike forbindelser kan anvendes i farmasøytiske sammensetninger og fremgangsmåter for behandling av sykdomstilstander, forstyrrelser og tilstander mediert av TRPVI. Således kan forbindelsene administreres for å behandle for eksempel smerte, kløe, hoste, astma eller inflammatorisk tarmsykdom.
