Disclosed herein are an α 1/CaV3.1 double knockout mouse or α 1-/-Emx1-Cre mouse with enhanced essential tremor and a screening method of therapeutic agents for essential tremor by using the same. The α 1/CaV3.1 double knockout mouse or α 1-/-Emx1-Cre mouse of the present invention may be usefully used for development of therapeutic agents for essential tremor because the mouse exhibits essential tremor strong and evident enough to be visually confirmed, compared to an α 1 knockout mouse.
