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Sposób wytwarzania kompozycji farmaceutycznej w postaci tabletek o przedłużonym uwalnianiu zawierających pirfenidon i jej zastosowanie w regresji przewlekłej niewydolności nerek, przykurczu torebkowego piersi zwłóknienia wątroby u ludzi.
专利权人:
CELL THERAPY AND TECHNOLOGY; S.A. DE C.V.
发明人:
Armendariz Borunda, Juan,Magaña Castro, José Augustin Rogelio,Cervantes Guadarrama, Jorge
申请号:
PL15161929
公开号:
PL2907506T3
申请日:
2012.07.13
申请国别(地区):
PL
年份:
2018
代理人:
摘要:
The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-± and anti-TGF-²1 action for the treatment of hepatic fibrosis.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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