Sposób wytwarzania kompozycji farmaceutycznej w postaci tabletek o przedłużonym uwalnianiu zawierających pirfenidon i jej zastosowanie w regresji przewlekłej niewydolności nerek, przykurczu torebkowego piersi zwłóknienia wątroby u ludzi.
Armendariz Borunda, Juan,Magaña Castro, José Augustin Rogelio,Cervantes Guadarrama, Jorge
申请号：
PL15161929
公开号：
PL2907506T3
申请日:
2012.07.13
申请国别(地区):
PL
年份:
2018
代理人:
摘要：
The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis； it shows a better activity with regard to the reduction and/or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-± and anti-TGF-²1 action for the treatment of hepatic fibrosis.
