CLARKE, ADAM, WILLIAM,DOYLE, ANTHONY GERARD,JENNINGS, PHILIP, ANTHONY,POULTON, LYNN, DOROTHY,WAI, BERNADETTE,POW, ANDREW, JAMES
申请号：
MYPI 2011000625
公开号：
MY153074A
申请日:
2009.08.14
申请国别(地区):
MY
年份:
2014
代理人:
摘要：
THE PRESENT INVENTION PROVIDES AN ANTIBODY COMPRISING AN ANTIGEN BINDING DOMAIN WHICH BINDS TO HUMAN IL-12 AND HUMAN IL-23. THE ANTIBODY BINDS HUMAN IL-12P40 EXISTING AS A MONOMER (HUMAN IL-12P40) AND AS A HOMODIMER (HUMAN IL-12P80) AND THE ANTIBODY INHIBITS THE BINDING OF HUMAN IL-12 TO HUMAN IL-12Rβ2 AND HUMAN IL-23 TO HUMAN IL-23R BUT DOES NOT INHIBIT THE BINDING OF HUMAN IL-12 OR HUMAN IL-23 OR HUMAN IL-12P40 OR HUMAN IL-12P80 TO HUMAN IL-12Rβ1.
