Stabilized trimeric HIV-1 GP41 fusion inhibitor polypeptides comprising the N-terminal heptad repeat (NHR) and foldon (FD) trimerization motif

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专利权人:

发明人:

Shibo Jiang,Zhi Qi,Xi Chen,Chungen Pan

申请号：

US14796725

公开号：

US09724383B2

申请日:

2015.07.10

申请国别(地区):

US

年份:

2017

代理人:

摘要：

Disclosed herein are trimeric polypeptide pharmaceutical compositions comprising three monomers, each monomer comprising a polypeptide having the amino acid sequence of the N-terminal heptad repeat (NHR or HR1) or C-terminal heptad repeat (CHR or HR2) of the transmembrane glycoprotein of human immunodeficiency virus (HIV) and a trimerization motif.

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中国工程科技知识中心

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