DAVE AXAY MUKUNDRAY,KUMAR RAJIV,PATEL DHIMANT JASUBHAI,DWIVEDI SHRIPRAKASH DHAR
申请号：
IN862/MUM/2006
公开号：
IN256958B
申请日:
2006.06.05
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
This invention relates to a new process for preparation of enantiomerically pure dapoxetine or an acid addition salt thereof i.e. S(+)-N,N-dimethyl-2-[2-(naphthalenyl oxy)ethyl]benzenemethanamine hydrochoride, a potent serotonin re-uptake inhibitor (SSRI), which comprises resolving racemic (±)-dapoxetine i.e. (±)- N,N-dimethyl-2-[2-(naphthalenyloxy)ethyl] benzene methanamine with a chiral acid so as to obtain salt of the chiral acid and (+)-dapoxetine, substantially free from (-)-dapoxetine.
