This invention relates to semi-solid compositions and semi-solidpharmaceutical products for use in the photodynamictreatment (PDT) of cancer, pre-cancerous conditions and non-cancerousconditions in the female reproductive system, theanus and the penis, preferably for use in PDT of endometrial, cervical,vulvar, vaginal, anal and penile dysplasia and HPV infectionsof the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical productscomprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or aprecursor or derivative of 5-ALA or pharmaceuticallyacceptable salts thereof. The invention relates further to methods of PDT ofcancer, pre-cancerous conditions and non-cancerousconditions in the female reproductive system, the anus and the penis, whereinsaid semi-solid compositions and pharmaceuticalproducts are used.