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DERIVE DE TETRAHYDROISOQUINOLINE
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
UTO, YOSHIKAZU,KARASAWA, HIROSHI,TAKAISHI, KIYOSUMI
申请号:
CA2719721
公开号:
CA2719721C
申请日:
2009.03.24
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention relates to a compound or apharmacologically acceptable salt thereof having anexcellent DGAT inhibitory effect and feeding suppressanteffect. The present invention provides a compoundrepresented by the general formula (I), orpharmacologically acceptable salt thereof:(see formula I)[wherein,R1 represents a phenylaminocarbonyl group that maybe substituted with 1 to 5 group(s) independentlyselected from Substituent Group A, a benzoxazol-2-ylgroup that may be substituted with 1 to 3 group(s)independently selected from Substituent Group A, or thelike; R2 independently represents a C1-C6 alkyl group; R3represents a group represented by the formula -C(=O)-O-R4or the like; R4 represents a hydrogen atom, a C1-C6 alkylgroup that may be substituted with 1 to 3 group(s)independently selected from Substituent Group B, or thelike; X represents an oxygen atom, a methylene group, ora group represented by the formula -NH-, or the like; Lrepresents a single bond, a methylene group, or thelike;...... represents a single bond or a double bond; mrepresents 1 or 2; n represents an integer of 0 to 5;Substituent Group A represents a halogen atom, a C1-C6alkyl group, a C1-C6 halogenated alkyl group, a C1-C6alkoxy group, or the like; and Substituent Group Brepresents a C3-C6 cycloalkyl group, a phenyl group, acarboxyl group, or the like].
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