The present invention relates to oral disintegrating tablets containing Nelfinavir mesylate and process for the preparation thereof. Particularly, the present invention relates to pre concentrated microemulsion pharmaceutical formulations of Nelfinavir mesylate (NFM) and its immediate delivery with enhanced oral bioavailability. The developed NFM ODT formulations disintegrate in 10-20s with tablet crushing strength of 4-5 kg and meets pharmacopoeial requirements. The developed NFM ODTs was found to have high relative oral bioavailability (208-239%) as compared to NFM suspension suggesting, quick and high therapeutic activity. The developed NFM-ODTs probably follows lymphatic delivery system thereby, could be effective to target viral sanctuaries located in brain and lymph region during HIV treatment. In addition, the developed NFM-ODTs formulations have high patient compliance belonging to class of geriatrics and pediatrics.
