A system of laser drilling machine is disclosed, which at least includes: one feeder alignment system, two sets of material feeding mechanism, one cycling conveyor driving system, one vertical conveyor driving system and its related inspections, and a laser machine. When the feeder alignment system coordinates with the cycling conveyor driving system through the material feeding mechanisms, a tablet drilling on round or cylindrical tablets in similar sizes can be conducted when the feeder alignment system coordinates with the vertical conveyor driving system, a tablet drilling on tablets having a bigger difference in sizes can be rapidly conducted. Accordingly, with the aforementioned combinations, the general tablet drilling on round or cylindrical tablets can be performed within a certain range of sizes, which solves the problem of needing another laser drilling machine to do tablet drilling in different shapes or sizes in conventional art hence, the disclosed is more cost-saving.一種雷射打孔機系統,至少包含有:一供料整列系統、二組送料機構、一環式輸送機傳動系統、一直式輸送機傳動系統及相關的檢測、雷射機而組成;當供料整列系統以送料機構配合環式輸送機傳動系統,能進行尺寸差異不大的圓形或圓柱形藥錠打孔;而以供料整列系統搭配直式輸送機傳動系統能快速對尺寸差異大的藥錠進行打孔,藉由上述系統的組合,能通用在一定尺寸範圍內,對於常用的圓形及圓柱形藥錠進行打孔,解決習用不同形狀或大小的藥錠就要換一套雷射打孔機,成本更為節省。10‧‧‧供料整列系統101‧‧‧平台11‧‧‧料筒110‧‧‧震動盤12‧‧‧離心轉盤13‧‧‧整列轉盤14‧‧‧檢出單元15‧‧‧滑軌20‧‧‧直式輸送機傳動系統21‧‧‧傳動輪組22‧‧‧輸送帶23‧‧‧輸送帶24‧‧‧間距30‧‧‧環式輸送機傳動系統31‧‧‧分度盤32‧‧‧料孔40‧‧‧送料機41‧‧‧送料導軌42‧‧‧振動器43‧‧‧進氣通道40’‧‧‧送料機41’‧‧‧送料導軌42’‧‧‧振動器43’‧‧‧進氣通道50‧‧‧藥錠穩定阻尼器80‧‧‧雷射機