DEEPSHIKHA PANDE KATARE,JOHN E MOSES,S k jain,HARSHA KHARKWAL,PALLAVI SHARMA,KUMUD BALA,D D JOSHI
申请号：
IN1239/DEL/2012
公开号：
IN2012DE01239A
申请日:
2012.04.23
申请国别(地区):
IN
年份:
2015
代理人:
摘要：
The present invention relates to the target drug delivery system using silymarin-drug conjugates for liver hepatocytes as anti-cancer agents. The present invention also relates to the development of conjugate silibinin to a number of known anticancer agents (such as curcummin, sarofanib, taxol etc.) by a linker which, in principle, should be delivered selectively to liver cells via the silibinin complex. The linker could either be permanent that requires the drug-silibinin conjugate to act as a delivery vector and active drug or, that the linker is cleaved once inside the cell, thus releasing the active drug and silibinin (silibinin itself is a potential cancer drug). This novel anti-cancer conjugates prepared by click chemistry which proves to be more effective treating liver carcinoma and prepared with a formulation which can control bioavailability of the drug increases the potency of the treatment.
