PROBLEM TO BE SOLVED: To provide an anti-human nerve growth factor (NGF) antibody or an antigen-binding fragment thereof that is excellent in safety by reducing the risk of side effects such as effects on a fetus and thrombus formation, and adverse events associated with joints such as rapidly progressive osteoarthritis, while maintaining high neutralizing activity, and to provide means for preventing or treating various diseases in which human NGF is involved in the formation of pathological conditions, by using the antibody or the antibody-binding fragment thereof.SOLUTION: Disclosed is an anti-human NGF antibody Fab' fragment comprising a heavy-chain variable region consisting of a specific amino acid sequence and a light-chain variable region consisting of a specific amino acid sequence. In the present invention, the heavy chain constant region of the Fab' fragment is a human Igγ1 constant region, and the light-chain constant region of the Fab' fragment is a human Ig&kgr; constant region. The anti-h
