An ultrasonic eye cleaning device comprises a body having an internal cavity and an end. The device further comprises a motor within the internal cavity, wherein the motor has a rotating output member. The device further comprises a chuck driven by the rotating output member of the motor. The device further comprises a piezo driver cooperating with the body and at least one of the rotating output member or the chuck to oscillate the chuck at 20 kHz to 100 MHz. The device further comprises an instrument that is attachable to the chuck and defining a free end forming a cleaning swab.