MALYSHEVA, ANNA OLEGOVNA,KLEMENTYEVA, OLGA EVGENIEVNA,KODINA, GALINA EVGENIEVNA,KORSUNSKY, VALENTIN NIKOLAEVICH,NAZARENKO, MIHAIL EVGENIEVICH,MIHAYLOV, OLEG ROTISLAVOVICH,PERMINOV, SERGEI VLADIMIROVIC
申请号：
EP08877097
公开号：
EP2351758A4
申请日:
2008.12.05
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
The invention relates to the new metal complexes of the formula M(O) K H m A n- , wherein M is the isotope of Tc, Re, Sm, Lu, Y, H is the hydrogen, A 5- is the anion of the zoledronic acid, wherein, when M is the technetium, then K=1, m=1, n=2 when M is the rhenium, then K=1, m=1, n=2 when M is the samarium, lutetium, or yttrium, then K=0, m=2, n=3, and their pharmaceutically eligible salts, hydrates, or isomers. The invention also relates to the method of production of the metal complex, wherein the lyophilizate obtained by mixing the zoledronic acid and tin dichloride solutions in the hydrochloric acid under inert gas and adding a hydroxide of an alkaline metal is mixed with a salt of a metal from the isotopes group and a radionuclide solution. What is proposed is the radiopharmaceutical that contains the metal complexes, their pharmaceutically eligible salts, hydrates, or isomers, and antioxidant, and the method of production of the radiopharmaceutical, wherein the lyophilizate is mixed with the solution containing a salt of a metal from the isotopes group and the radionuclide solution.
