Z.H.T. ENGINEERING EQUIPMENT AND TECHNOLOGIES LTD.;BENZION GESHURI
发明人:
BENZION GESHURI
申请号：
IL19226208
公开号：
IL192262A
申请日:
2008.06.17
申请国别(地区):
IL
年份:
2016
代理人:
摘要：
The present invention provides a Monodisperse Polymer Particles (MPP) adapted to release alkoxy groups by means of a hydrolyser, such that Monodisperse Bioactive Polymer Particles (MBPP) are obtained in vivo. The MBPP are characterized by (a) at least one naturally occurring or synthetic long molecular chain consisting of biologically stable backbones optionally crosslinked, further characterized by a molecular weight of at least 1 KD, comprising between 10 to 1,000,000 repeated covalently-linked small molecules with a functionality of at least one alkoxy releasing group per molecule； (b) a long dimension between 0.1 and 10 micrometers； and, (c) a zeta potential value of 30 to 130 mV at pH of about 7.0. The MBPP alter, inhibit, activate, induce or otherwise affect biological or chemical events in vivo.
