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COMPOSITION PHARMACEUTIQUE QUI COMPREND UN ACIDE 2,5 - DIHYDROXYBENZÈNOSULPHONIQUE OU UN DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES EN FORME D'UNITÉS INDIVIDUALISÉES D'ADMINISTRATION ET PROCÉDÉ DE FABRICATION CORRESPONDANT
专利权人:
BELAC INVEST; S.L.;BELAC INVEST, S.L.
发明人:
INATTI MARTINEZ, Alfredo José
申请号:
ESES2018/070123
公开号:
WO2018/154161A1
申请日:
2018.02.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Pharmaceutical composition comprising 2,5-dihydroxybenzenesulfonic acid or a pharmaceutically acceptable salt thereof in the form of personalised supply units and the corresponding manufacturing method. Pharmaceutical composition comprising 2,5-dihydroxybenzenesulfonic acid or a pharmaceutically acceptable salt thereof in the form of personalised supply units, in which part of the 2,5-dihydroxybenzenesulfonic acid is in the form of an immediate-release composition additionally comprising between 8% and 28% microcrystalline cellulose, and the other part of which is in the form of a prolonged-release composition additionally comprising between 10% and 45% hydroxypropylmethylcellulose and between 6.1% and 20% hydroxypropylcellulose. The proportion between the two parts is between 24:76 and 40:60. This allows administration of the composition to the patient once every 24 hours. The composition can be used to treat primary varicose states, chronic venous insufficiency, phlebitis, thrombophlebitis, post-thrombotic syndrome, leg ulcers, pregnancy-related varicose veins. as a coadjuvant for varicectomy, sclerotherapy or as a coadjuvant in the treatment of diabetic retinopathy.Composición farmacéutica que comprende ácido 2,5 – dihidroxibencenosulfónico o una de sus sales farmacéuticamente aceptables en forma de unidades individualizadas de suministro y procedimiento de fabricación correspondiente. Composición farmacéutica que comprende ácido 2,5 – dihidroxibencenosulfónico o una de sus sales en forma de unidades individualizadas de suministro, en la que una parte del ácido 2,5 – dihidroxibencenosulfónico está en forma de composición de liberación inmediata, que comprende, adicionalmente entre un 8% a 28% de celulosa microcristalina, y otra parte está en forma de composición de liberación prolongada, que comprende, adicionalmente entre un 10% a 45% de hidroxipropilmetilcelulosa y entre un 6,1% a 20% de hidroxipropilcelulosa. La proporción entre las dos partes está comprendida
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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