Multilumen catheters are provided. The subject multilumen catheters (10)include a proximal end (14) and a distal end (12) separated by a non-coaxialmultilumen tube. The subject catheters are further characterized in that theyinclude a multiport manifold (18) at their proximal ends, where at least twoof the ports (11a, 11c) of the multiport manifold may comprise luer valves(15a, 15c). Also provided are systems for use in flushing a vascular site withfluid, usually at least two different fluids, where the subject systems aremade up of two multilumen catheters according to the subject invention, whereone of the catheters is inserted inside of the other. In addition, kitscomprising various components of the subject systems, e.g., at least twodifferent multilumen catheters, are provided. The subject multilumencatheters, systems and kits find use in a variety of different applications inwhich it is desired to flush a vascular site with at least one and preferablytwo different fluids, where particular applications of interest include thetreatment of vascular lesions.