Methods for controlled proliferation of stem cells / generating inner ear hair cells using GSK-3-alpha inhibitors

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专利权人:

Frequency Therapeutics; Inc.

发明人:

Loose, Christopher,McLean, Will,Harrison, Megan

申请号：

AU2017227844

公开号：

AU2017227844A1

申请日:

2017.03.02

申请国别(地区):

AU

年份:

2018

代理人:

摘要：

Provided are compositions and methods for inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells, and including compositions and methods of using GSK3-alpha inhibitors, and salts thereof, optionally in combination with a Differentiation Inhibitor such as a Notch agonist or an HDAC inhibitor (e.g., valproic acid).

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/