Dominic Paul DAgostino,Jay B. Dean,Raffaele Pilla,Patrick Arnold
申请号：
US14078066
公开号：
US20140073693A1
申请日:
2013.11.12
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention demonstrates the therapeutic use of ketone esters for seizure disorders, Alzheimers disease and malignant brain cancer, which are associated with metabolic dysregulation. The administration of ketone esters resulted therapeutic ketosis and neuroprotection against seizures resulting from CNS oxygen toxicity. Supplemental ketones were also found to reduce superoxide production in cultured cortex neurons exposed to hyperbaric oxygen and Aβ-42, and to decrease proliferation and viability in U87 glioma cells. These observations support the therapeutic effect of ketones for seizure disorders, Alzheimers disease and malignant brain cancer. The ketone esters may be derived from acetoacetate and can include R,S-1,3-butanediol acetoacetate monoester, R,S-1,3-butanediol acetoacetate diester, or a combination of the two.
