Stephen D. Gillies,Nigel John Watkins,Matthew Paul Baker,Kin-Ming Lo,Steven C. Degon
申请号：
US12395165
公开号：
US08557232B2
申请日:
2009.02.27
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are Fc-interferon-beta (Fc-IFN-β) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-β fusion proteins include variants of the interferon-beta (IFN-β) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.
