The present invention relates a drug delivery device for dispensing of a dose of a medicament, comprising: an elongated body (20) extending in an axial direction (1, 2), a cartridge holder (13) to accommodate a cartridge (12) at least partially filled with the medicament and having an axially displaceable piston (14), a piston rod (110) to operably engage with the piston (14) of the cartridge (12) to displace the piston (14) in axial distal direction (1), a coupling member (100) connected with the cartridge holder (13) and being axially displaceably arranged in the body (20) for retracting the cartridge holder (13) into the body (20) during setting of a dose.
