STOCK, NICHOLAS SIMON,CHEN, AUSTIN CHIH-YU,BRAVO, YALDA MOSTOFI,JACINTHO, JASON DUARTE,BACCEI, JILL MELISSA,STEARNS, BRIAN ANDREW,CLARK, RYAN CHRISTOPHER
申请号：
PE0010312015
公开号：
PE15212015A1
申请日:
2013.12.10
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Triazolone derivatives relates to compounds of formula I, and their pharmaceutically acceptable salts thereof, wherein A1 is a phenyl Ring or heteroaromatico 6 Member containing 1,2 or 3 n Atoms A2 is A2A or A2B, where A2A is phenyl or a six member Ring heteroaromatico containing 1, 2 or 3 n Atoms and A2B is a Five Member Ring heteroaromatico containing 1,2 or 3 heteroatoms selected irrespective of o, s and N X is - (CH2) M - (CH2) - M - O - N - (CH2), - (CH2) NH (CH2) - M - N -, S - (CH2) M - (2 - (CH2) n -, among others), where M and N are independently 0, 12, 3 or 4 and o u s R1 and R2 are independently h, halogen, alkyl of C1 CN, CF3, - 6, - so2h NHC (NH2, Oh, o), NHS (or cycloalkyl) 2h, c3-6, so2nh2, CONH2, R5 is H, among others alkyl C1 - 6Aryl, heteroaryl cycloalkyl, c3-6, among others and R6 is H, alkyl alkylaryl C1 C1 - 6, - 6, - 6 alquilheteroarilo C1, among others.The compounds of formula I are antagonists of PPAR alpha and therefore useful in the treatment of cancers of the Prostate, Breast, Colon, pancreas, Human Chronic Lymphocytic Leukemia, melanoma,Among others. It also relates to pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salts thereof.The products of the invention are also useful in the treatment of Viral Infections, such as Infections by HCV or HIVSE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLONA DE FORMULA I Y SUS SALES FARMACEUTICAMENTE ACEPTABLES, CARACTERIZADOS PORQUE A1 ES FENILO O UN ANILLO HETEROAROMATICO DE 6 MIEMBROS CONTENIENDO 1, 2 o 3 ATOMOS DE N A2 ES A2a O A2b, DONDE A2a ES FENILO O UN ANILLO HETEROAROMATICO DE 6 MIEMBROS CONTENIENDO 1, 2 o 3 ATOMOS DE N Y A2b ES UN ANILLO HETEROAROMATICO DE 5 MIEMBROS CONTENIENDO 1, 2 o 3 HETEROATOMOS SELECCIONADOS INDEPENDIENTEMENTE ENTRE O, S y N X ES -(CH2)m-, -(CH2)m-O-(CH2)n-, -(CH2)m-NH-(CH2)n-, -(CH2)m-S(O)2-(CH2)n-, ENTRE OTROS, DONDE m Y n SON INDEPENDIENTEMENTE 0, 1, 2, 3 o 4 Y ES O u S R1 Y R2 SON INDEPENDIENTEMENTE H, HALOGENO, CN, CF3,
