Juan Francisco Marquez Ruiz;John Francis Gilmer;Dermot Kelleher
发明人:
John Francis Gilmer,Juan Francisco Marquez Ruiz,Dermot Kelleher
申请号：
US13141663
公开号：
US20120094963A1
申请日:
2009.12.21
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are compounds of formula (I) as well as compounds of formula (I) which are prodrugs in which the (R7)a-phenyl-S(O)2NH group represents a sulphonamide-bond compound, compositions and methods for preventing or treating gastrointestinal diseases such as inflammatory bowel disease and colorectal cancer, wherein the method comprises delivering an effective amount of a COX-2 or a similar sulphonamide inhibitor as a prodrug or a derivative thereof to the colon, wherein the COX-2 or similar inhibitor is released in vivo.
