The present invention related to compositions including berberine orderivatives thereof of formula (1) (where R1, R2, R3, R4, R5, R6, R7, R8, R9,R10, R11, R12 and X are as defined in claim 1) and/or polymeric dialdehydechosen from compounds such as dialdehyde polysaccharides (such as oxidisedcellulose (oxycellulose) or oxidized starch (oxystarch) orpoly(acrolein/acrylic acid) for the treatment of gastrointestinal functionaldisorders and related conditions, including Irritable Bowel Syndrome；Inflammatory Bowel Disease； Colitis,Crohn~s disease and/or for promotingweight gainin animals including humans.
