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Formulations with reduced degradation of polysorbate
专利权人:
Inc.;Genentech
发明人:
Connolly, Brian,Hamburg, Lydia,Holz, Emily
申请号:
AU2016380988
公开号:
AU2016380988A1
申请日:
2016.12.28
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The invention provides methods for making such formulations and methods of using such formulations. The invention further provides methods of reducing polysorbate degradation, methods of reducing the amount of visible and sub-visible particles in an aqueous formulation, and methods of disaggregating polysorbate degradation products comprising adding a cyclodextrin to a formula comprising polysorbate and a polypeptide. The invention also provides aqueous formulations comprising a polypeptide, a polysorbate, and a cyclodextrin with reduced polysorbate degradation.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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