#$%^&*AU2017228688A120171005.pdf#####: aar Interwovn NRPortbl DCC AAR 15687436_ docx-I4 09/2017 ABSTRACT OF THE DISCLOSURE The present invention relates to novel antibodies and fragments that bind to a Vdomain Ig Suppressor of T cell Activation (VISTA), and methods of making and using same. Methods of use include methods of treatment of cancer, including leukemias, lymphomas, solid tumors and melanomas.