SYSTEMIC TARGETING OF INFLAMMATORY SITES AND ENHANCED IMMUNOMODULATORY FUNCTION BY INTRODUCING THE CHIMERIC ANTIGEN RECEPTOR (CAR) INTO MESENCHYMAL STEM CELLS FOR INFLAMMATORY AND AUTOIMMUNE DISEASES
The Board of Trustees of the Leland Stanford Junior University
发明人:
Tzuhua Dennis Lin,Stuart B. Goodman,Sai-Wen Tang,Everett Hurteau Meyer,Magdiel Pérez Cruz
申请号：
US16371371
公开号：
US20190298774A1
申请日:
2019.04.01
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Mesenchymal stromal cells are engineered to express a chimeric antigen receptor (CAR), that specifically binds a marker of activated myeloid cells, including without limitation folate receptor beta； and are administered to an individual for treatment of inflammation at sites characterized by the presence of activated myeloid cells.
