The present invention relates to solid microparticulate oral pharmaceutical forms which have a composition and a structure that prevents the misuse of the active pharmaceutical ingredient (API) contained therein. The aim of the present invention is to prevent the improper use of solid oral drugs for any use other than the therapeutic use(s) officially approved by the appropriate public health authorities. In other words, it is a question of preventing the voluntary or involuntary misuse of solid oral drugs. The invention relates to a solid oral pharmaceutical form, characterized in that it comprises anti-misuse means, in that at least part of the API that it contains is contained in coated microparticles for modified API release, and in that the coated API microparticles comprise a coating layer (Ra), which ensures modified release of the API and which, simultaneously, confers resistance to crushing on the coated API microparticles, so as to prevent misuse.
