GLUCAGON-LIKE PEPTIDE-1 ANALOGUE AND USE THEREOF AbstractProvided is a glucagon-like peptide-1 (GLP-1) analogue shown as the followingformula, wherein X is selected from glycine and glycinamide. The GLP-1 analogue has a non-proteogenic amino acid residue in position 8 relative to the sequence GLP-1, and is acylated with a moiety comprising two acidic groups to the lysine residue in position 26. The GLP-1 analogue is resistant to dipeptidyl peptidase IV so as to have an extendedhalf-life in vivo. Also provided is a use of the GLP-1 analogue in conquering blood sugar. H—His'..N Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-lle-Ala-Trp-Leu-Val-Arg-Gly-Arg-XCF3
